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028) in patients with cirrhosis, and 0.68% vs. 2.94% (p?Urease Gender, HBV DNA, Core promoter mutations and Cirrhosis (GAG-HCC), have been developed using data from two independent Hong Kong cohorts ?and?. The latter two models highlight Atorvastatin purchase that cirrhosis is an important risk factor for HCC in Asians; although without a biopsy, detection of cirrhosis in routine practice is neither sensitive nor standardized . Non-invasive measurements of liver fibrosis such as transient elastography may enhance the accuracy of these models; however, further studies are needed . An important question is whether HCC risk predictors are also applicable in patients receiving antiviral therapy, as this generally Belinostat clinical trial results in HBV DNA suppression and sometimes also regression of cirrhosis , ?and?. The accuracy of REACH-B, CU-HCC, and GAG-HCC has been confirmed in entecavir-treated patients in one cohort from Hong Kong, and seems to increase from year 2 of therapy onwards compared with baseline . However, these models were reported to offer poor accuracy for the prediction of HCC in European Caucasian patients receiving antiviral therapy ?and?. In mostly Caucasian European patients under entecavir or tenofovir therapy, a new score named PAGE-B has recently been developed; in this score, which included age, gender, and platelet counts probably reflecting the severity of liver disease, the addition of cirrhosis did not substantially improve the discrimination . The variables included in all these models can be conceptually divided into three categories: (i) variables that are readily modifiable by antiviral therapy, namely HBV DNA and alanine aminotransferase (ALT); (ii) variables that can potentially be altered with long-term antiviral therapy, namely albumin, bilirubin, platelets, HBeAg status, and, ultimately, cirrhosis; and (iii) variables that are not affected, namely age and gender. Examination of the weights associated with these variables may be instructive in estimating the impact on HCC risk that could potentially be attributed to antiviral therapy by the different risk scores.